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GO:0004693 'cyclin-dependent protein serine/threonine kinase activity'

Cvterm details 
Term idGO:0004693
Term namecyclin-dependent protein serine/threonine kinase activity
Term definitionCatalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
Comment

Synonyms
ATP:cyclin phosphotransferase activity EXACT EC:2.7.11.22
cdc2 kinase activity NARROW EC:2.7.11.22
CDK RELATED EC:2.7.11.22
CDK activity EXACT
CDK, catalytic subunit activity EXACT
cdk-activating kinase activity EXACT EC:2.7.11.22
Cdk-activating protein kinase activity EXACT EC:2.7.11.22
cyclin D-cdk6 kinase activity NARROW EC:2.7.11.22
cyclin D-dependent kinase activity NARROW EC:2.7.11.22
cyclin E kinase activity NARROW EC:2.7.11.22
cyclin-A associated kinase activity NARROW EC:2.7.11.22
cyclin-dependent kinase 6 activity NARROW EC:2.7.11.22
cyclin-dependent kinase activity BROAD EC:2.7.11.22
cyclin-dependent kinase-2 activity NARROW EC:2.7.11.22
cyclin-dependent kinase-4 activity NARROW EC:2.7.11.22
cyclin-dependent protein kinase, intrinsic catalyst activity EXACT
D-type cyclin kinase activity NARROW EC:2.7.11.22
neuronal cdc2-like kinase activity NARROW EC:2.7.11.22
"ATP:cyclin phosphotransferase activity" EXACT [EC:2.7.11.22]
"cdc2 kinase activity" NARROW [EC:2.7.11.22]
"CDK" RELATED [EC:2.7.11.22]
"CDK activity" EXACT []
"CDK, catalytic subunit activity" EXACT []
"cdk-activating kinase activity" EXACT [EC:2.7.11.22]
"Cdk-activating protein kinase activity" EXACT [EC:2.7.11.22]
"cyclin D-cdk6 kinase activity" NARROW [EC:2.7.11.22]
"cyclin D-dependent kinase activity" NARROW [EC:2.7.11.22]
"cyclin E kinase activity" NARROW [EC:2.7.11.22]
"cyclin-A associated kinase activity" NARROW [EC:2.7.11.22]
"cyclin-dependent kinase 6 activity" NARROW [EC:2.7.11.22]
"cyclin-dependent kinase activity" BROAD [EC:2.7.11.22]
"cyclin-dependent kinase-2 activity" NARROW [EC:2.7.11.22]
"cyclin-dependent kinase-4 activity" NARROW [EC:2.7.11.22]
"cyclin-dependent protein kinase, intrinsic catalyst activity" EXACT []
"D-type cyclin kinase activity" NARROW [EC:2.7.11.22]
"neuronal cdc2-like kinase activity" NARROW [EC:2.7.11.22]
"cyclin-dependent protein kinase activity" BROAD []

Definition dbxrefs

Related dbxrefs
GO:0016537
EC:2.7.11.22
MetaCyc:2.7.11.22-RXN
Reactome:REACT_100142 "Phosphorylation of Cdh1 by Cyclin B1
Reactome:REACT_100284 "Phosphorylation of E2F1/E2F3 by Cyclin A
Reactome:REACT_100368 "Phosphorylation of M phase proteins by active Cyclin B1
Reactome:REACT_100867 "Phosphorylation of M phase proteins by active Cyclin B1
Reactome:REACT_101084 "Phosphorylation of M phase proteins by active Cyclin B1
Reactome:REACT_101412 "Cyclin D
Reactome:REACT_101652 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Mus musculus"
Reactome:REACT_102726 "Phosphorylation of E2F1/E2F3 by Cyclin A
Reactome:REACT_102799 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B
Reactome:REACT_103183 "Cyclin D
Reactome:REACT_103312 "Cyclin E/A
Reactome:REACT_103830 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Bos taurus"
Reactome:REACT_104343 "Phosphorylation of M phase proteins by active Cyclin B1
Reactome:REACT_104830 "Cyclin D
Reactome:REACT_106008 "Cyclin E/A
Reactome:REACT_106596 "Cyclin E/A
Reactome:REACT_107107 "Cyclin E
Reactome:REACT_107135 "CDK5 phosphorylates DARPP-32 on Thr75, Rattus norvegicus"
Reactome:REACT_107346 "Cyclin A
Reactome:REACT_107592 "Cyclin A
Reactome:REACT_108100 "Cyclin A
Reactome:REACT_109124 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Rattus norvegicus"
Reactome:REACT_109419 "Phosphorylation of Cdh1 by Cyclin A
Reactome:REACT_109597 "CDK5 phosphorylates DARPP-32 on Thr75, Canis familiaris"
Reactome:REACT_110505 "Phosphorylation of Cdh1 by Cyclin A
Reactome:REACT_110542 "Cyclin D
Reactome:REACT_111206 "Cyclin D
Reactome:REACT_111248 "Cyclin D
Reactome:REACT_112082 "Cyclin D
Reactome:REACT_112868 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Xenopus tropicalis"
Reactome:REACT_113042 "Phosphorylation of Cdh1 by Cyclin B1
Reactome:REACT_113645 "Cyclin E
Reactome:REACT_113808 "Phosphorylation of Cdh1 by Cyclin B1
Reactome:REACT_113866 "Phosphorylation of M phase proteins by active Cyclin B1
Reactome:REACT_115193 "CDK5 phosphorylates DARPP-32 on Thr75, Xenopus tropicalis"
Reactome:REACT_115457 "Phosphorylation of M phase proteins by active Cyclin B1
Reactome:REACT_15365 "CDK5 phosphorylates DARPP-32 on Thr75, Homo sapiens"
Reactome:REACT_15543 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Homo sapiens"
Reactome:REACT_1627 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2
Reactome:REACT_1882 "Cyclin D
Reactome:REACT_28043 "Phosphorylation of Cdh1 by Cyclin A
Reactome:REACT_28206 "Cyclin E/A
Reactome:REACT_28927 "Phosphorylation of M phase proteins by active Cyclin B1
Reactome:REACT_29737 "Phosphorylation of Cdh1 by Cyclin A
Reactome:REACT_30547 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B
Reactome:REACT_30560 "Free APC/C phosphorylated by Cyclin B
Reactome:REACT_30857 "Phosphorylation of Cdh1 by Cyclin B1
Reactome:REACT_30946 "Phosphorylation of Cdh1 by Cyclin A
Reactome:REACT_31143 "Phosphorylation of Cdh1 by Cyclin A
Reactome:REACT_32944 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B
Reactome:REACT_33000 "Cyclin E/A
Reactome:REACT_33255 "Phosphorylation of Cdh1 by Cyclin A
Reactome:REACT_33633 "Cyclin E
Reactome:REACT_33864 "Cyclin D
Reactome:REACT_34028 "Free APC/C phosphorylated by Cyclin B
Reactome:REACT_406 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A1
Reactome:REACT_46105 "Phosphorylation of E2F1/E2F3 by Cyclin A
Reactome:REACT_55912 "Cyclin A
Reactome:REACT_6338 "Phosphorylation of M phase proteins by active Cyclin B1
Reactome:REACT_6721 "Phosphorylation of Cdh1 by Cyclin A
Reactome:REACT_68077 "Phosphorylation of E2F1/E2F3 by Cyclin A
Reactome:REACT_6811 "Phosphorylation of Cdh1 by Cyclin B1
Reactome:REACT_6891 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B
Reactome:REACT_6942 "Free APC/C phosphorylated by Cyclin B
Reactome:REACT_77008 "Phosphorylation of E2F1/E2F3 by Cyclin A
Reactome:REACT_77473 "Cyclin A
Reactome:REACT_77863 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B
Reactome:REACT_78910 "Free APC/C phosphorylated by Cyclin B
Reactome:REACT_80990 "Free APC/C phosphorylated by Cyclin B
Reactome:REACT_81918 "Phosphorylation of Cdh1 by Cyclin B1
Reactome:REACT_82302 "CDK5 phosphorylates DARPP-32 on Thr75, Mus musculus"
Reactome:REACT_82539 "Phosphorylation of M phase proteins by active Cyclin B1
Reactome:REACT_82578 "Phosphorylation of Cdh1 by Cyclin B1
Reactome:REACT_83958 "CDK5 phosphorylates DARPP-32 on Thr75, Bos taurus"
Reactome:REACT_84020 "Phosphorylation of Cdh1 by Cyclin A
Reactome:REACT_84061 "Phosphorylation of Cdh1 by Cyclin B1
Reactome:REACT_84295 "Free APC/C phosphorylated by Cyclin B
Reactome:REACT_852 "Phosphorylation of proteins involved in G2/M transition by active Cyclin B2
Reactome:REACT_85707 "Phosphorylation of Cdh1 by Cyclin A
Reactome:REACT_85853 "Cyclin E
Reactome:REACT_86936 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B
Reactome:REACT_88269 "Cyclin E/A
Reactome:REACT_88622 "Phosphorylation of E2F1/E2F3 by Cyclin A
Reactome:REACT_89028 "Cyclin E
Reactome:REACT_89106 "Cyclin E
Reactome:REACT_89375 "Phosphorylation of E2F1/E2F3 by Cyclin A
Reactome:REACT_89502 "Phosphorylation of M phase proteins by active Cyclin B1
Reactome:REACT_8993 "Cyclin E
Reactome:REACT_8995 "Cyclin A
Reactome:REACT_8998 "Cyclin E/A
Reactome:REACT_9023 "Phosphorylation of E2F1/E2F3 by Cyclin A
Reactome:REACT_91084 "Cyclin E
Reactome:REACT_91609 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Danio rerio"
Reactome:REACT_92060 "Free APC/C phosphorylated by Cyclin B
Reactome:REACT_93696 "Phosphorylation of Cdh1 by Cyclin A
Reactome:REACT_93979 "Cyclin D
Reactome:REACT_94092 "Phosphorylation of Cdh1 by Cyclin B1
Reactome:REACT_96284 "Free APC/C phosphorylated by Cyclin B
Reactome:REACT_96884 "CDK5 phosphorylates DARPP-32 on Thr75, Danio rerio"
Reactome:REACT_96907 "Cyclin E/A
Reactome:REACT_98018 "Cyclin A
Reactome:REACT_98320 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Canis familiaris"
Reactome:REACT_98605 "Phosphorylation of Cdh1 by Cyclin B1
Reactome:REACT_99005 "Phosphorylation of Cdh1 by Cyclin A
Reactome:REACT_99017 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B
Reactome:REACT_99668 "Cyclin A

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