Term id	GO:0003887
Term name	DNA-directed DNA polymerase activity
Term definition	Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer.
Comment

Synonyms
alpha DNA polymerase activity NARROW
beta DNA polymerase activity NARROW
delta DNA polymerase activity NARROW
deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity EXACT EC:2.7.7.7
deoxyribonucleic acid duplicase activity EXACT EC:2.7.7.7
deoxyribonucleic duplicase activity EXACT EC:2.7.7.7
deoxyribonucleic polymerase I NARROW EC:2.7.7.7
DNA duplicase activity EXACT EC:2.7.7.7
DNA nucleotidyltransferase (DNA-directed) activity EXACT EC:2.7.7.7
DNA polymerase alpha NARROW EC:2.7.7.7
DNA polymerase beta NARROW EC:2.7.7.7
DNA polymerase gamma NARROW EC:2.7.7.7
DNA polymerase I NARROW EC:2.7.7.7
DNA polymerase II NARROW EC:2.7.7.7
DNA polymerase III NARROW EC:2.7.7.7
DNA polymerase V activity NARROW
DNA replicase activity EXACT EC:2.7.7.7
DNA-dependent DNA polymerase activity EXACT EC:2.7.7.7
duplicase BROAD EC:2.7.7.7
epsilon DNA polymerase activity NARROW
eta DNA polymerase activity NARROW
gamma DNA-directed DNA polymerase activity NARROW
iota DNA polymerase activity NARROW
kappa DNA polymerase activity NARROW
Klenow fragment NARROW EC:2.7.7.7
lambda DNA polymerase activity NARROW
mu DNA polymerase activity NARROW
nu DNA polymerase activity NARROW
sequenase RELATED EC:2.7.7.7
sigma DNA polymerase activity NARROW
Taq DNA polymerase NARROW EC:2.7.7.7
Taq Pol I NARROW EC:2.7.7.7
Tca DNA polymerase NARROW EC:2.7.7.7
theta DNA polymerase activity NARROW
zeta DNA polymerase activity NARROW
"alpha DNA polymerase activity" NARROW []
"beta DNA polymerase activity" NARROW []
"delta DNA polymerase activity" NARROW []
"deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7]
"deoxyribonucleic acid duplicase activity" EXACT [EC:2.7.7.7]
"deoxyribonucleic duplicase activity" EXACT [EC:2.7.7.7]
"deoxyribonucleic polymerase I" NARROW [EC:2.7.7.7]
"DNA duplicase activity" EXACT [EC:2.7.7.7]
"DNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7]
"DNA polymerase alpha" NARROW [EC:2.7.7.7]
"DNA polymerase beta" NARROW [EC:2.7.7.7]
"DNA polymerase gamma" NARROW [EC:2.7.7.7]
"DNA polymerase I" NARROW [EC:2.7.7.7]
"DNA polymerase II" NARROW [EC:2.7.7.7]
"DNA polymerase III" NARROW [EC:2.7.7.7]
"DNA polymerase V activity" NARROW []
"DNA replicase activity" EXACT [EC:2.7.7.7]
"DNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.7]
"duplicase" BROAD [EC:2.7.7.7]
"epsilon DNA polymerase activity" NARROW []
"eta DNA polymerase activity" NARROW []
"gamma DNA-directed DNA polymerase activity" NARROW []
"iota DNA polymerase activity" NARROW []
"kappa DNA polymerase activity" NARROW []
"Klenow fragment" NARROW [EC:2.7.7.7]
"lambda DNA polymerase activity" NARROW []
"mu DNA polymerase activity" NARROW []
"nu DNA polymerase activity" NARROW []
"sequenase" RELATED [EC:2.7.7.7]
"sigma DNA polymerase activity" NARROW []
"Taq DNA polymerase" NARROW [EC:2.7.7.7]
"Taq Pol I" NARROW [EC:2.7.7.7]
"Tca DNA polymerase" NARROW [EC:2.7.7.7]
"theta DNA polymerase activity" NARROW []
"zeta DNA polymerase activity" NARROW []

Definition dbxrefs

Related dbxrefs
GO:0003888
GO:0003889
GO:0003890
GO:0003891
GO:0003893
GO:0003894
GO:0003895
GO:0008723
GO:0015999
GO:0016000
GO:0016448
GO:0016449
GO:0016450
GO:0016451
GO:0016452
GO:0019984
MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN
Reactome:REACT_101168 "Misinsertion of bases opposite to the lesion by HREV1, Drosophila melanogaster"
Reactome:REACT_101456 "Elongation by HREV1 protein, Arabidopsis thaliana"
Reactome:REACT_101578 "The polymerase component of DNA polymerase alpha
Reactome:REACT_102164 "DNA strand displacement synthesis, Arabidopsis thaliana"
Reactome:REACT_1024 "Formation of Okazaki fragments, Homo sapiens"
Reactome:REACT_102850 "Elongation by Pol eta, Sus scrofa"
Reactome:REACT_102905 "Resynthesis of excised residue, Mus musculus"
Reactome:REACT_103072 "POL Beta mediated incorporation of the first replacement nucleotide, Taeniopygia guttata"
Reactome:REACT_103285 "Elongation by Pol zeta complex, Sus scrofa"
Reactome:REACT_103439 "Misinsertion of bases opposite to the lesion by HREV1, Taeniopygia guttata"
Reactome:REACT_103520 "Elongation by Pol zeta complex, Mus musculus"
Reactome:REACT_103531 "The polymerase component of DNA polymerase alpha
Reactome:REACT_104153 "Formation of Okazaki fragments, Arabidopsis thaliana"
Reactome:REACT_104851 "Elongation by HREV1 protein, Drosophila melanogaster"
Reactome:REACT_104914 "The polymerase component of DNA polymerase alpha
Reactome:REACT_104973 "Elongation by Pol eta, Arabidopsis thaliana"
Reactome:REACT_105070 "Insertion of correct bases opposite to the lesion by Pol eta, Saccharomyces cerevisiae"
Reactome:REACT_105462 "Formation of C-strand Okazaki fragments, Sus scrofa"
Reactome:REACT_105659 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Danio rerio"
Reactome:REACT_105733 "Elongation by HREV1 protein, Canis familiaris"
Reactome:REACT_105794 "Insertion of correct bases opposite to the lesion by Pol eta, Arabidopsis thaliana"
Reactome:REACT_105961 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Bos taurus"
Reactome:REACT_106002 "Resynthesis of excised residue, Rattus norvegicus"
Reactome:REACT_106057 "Insertion of correct bases opposite to the lesion by Pol eta, Drosophila melanogaster"
Reactome:REACT_106334 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Canis familiaris"
Reactome:REACT_106776 "Elongation by HREV1 protein, Caenorhabditis elegans"
Reactome:REACT_106994 "Formation of C-strand Okazaki fragments, Schizosaccharomyces pombe"
Reactome:REACT_107125 "Elongation by HREV1 protein, Rattus norvegicus"
Reactome:REACT_107358 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Danio rerio"
Reactome:REACT_107480 "Elongation by HREV1 protein, Schizosaccharomyces pombe"
Reactome:REACT_107781 "Misinsertion of bases opposite to the lesion by HREV1, Rattus norvegicus"
Reactome:REACT_107879 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Canis familiaris"
Reactome:REACT_107930 "Formation of Okazaki fragments, Mus musculus"
Reactome:REACT_108241 "Elongation by HREV1 protein, Xenopus tropicalis"
Reactome:REACT_108640 "The polymerase component of DNA polymerase alpha
Reactome:REACT_108802 "Elongation by Pol eta, Rattus norvegicus"
Reactome:REACT_109069 "Formation of Okazaki fragments, Oryza sativa"
Reactome:REACT_109329 "The polymerase component of DNA polymerase alpha
Reactome:REACT_109542 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Xenopus tropicalis"
Reactome:REACT_109593 "Formation of C-strand Okazaki fragments, Mus musculus"
Reactome:REACT_109749 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Rattus norvegicus"
Reactome:REACT_109858 "Insertion of correct bases opposite to the lesion by Pol eta, Bos taurus"
Reactome:REACT_109873 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Xenopus tropicalis"
Reactome:REACT_109947 "Misinsertion of bases opposite to the lesion by HREV1, Xenopus tropicalis"
Reactome:REACT_110252 "Formation of C-strand Okazaki fragments, Canis familiaris"
Reactome:REACT_112231 "Elongation by Pol zeta complex, Xenopus tropicalis"
Reactome:REACT_112289 "Elongation by Pol zeta complex, Taeniopygia guttata"
Reactome:REACT_112468 "Elongation by Pol zeta complex, Dictyostelium discoideum"
Reactome:REACT_1196 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Homo sapiens"
Reactome:REACT_1324 "Elongation by Pol zeta complex, Homo sapiens"
Reactome:REACT_1479 "Elongation by Pol eta, Homo sapiens"
Reactome:REACT_2016 "Insertion of correct bases opposite to the lesion by Pol eta, Homo sapiens"
Reactome:REACT_2214 "Misinsertion of bases opposite to the lesion by HREV1, Homo sapiens"
Reactome:REACT_2224 "POL Beta mediated incorporation of the first replacement nucleotide, Homo sapiens"
Reactome:REACT_28103 "The polymerase component of DNA polymerase alpha
Reactome:REACT_28619 "The polymerase component of DNA polymerase alpha
Reactome:REACT_28865 "The polymerase component of DNA polymerase alpha
Reactome:REACT_29011 "Elongation by Pol zeta complex, Gallus gallus"
Reactome:REACT_29030 "Formation of C-strand Okazaki fragments, Danio rerio"
Reactome:REACT_292 "Resynthesis of excised residue, Homo sapiens"
Reactome:REACT_29783 "Insertion of correct bases opposite to the lesion by Pol eta, Gallus gallus"
Reactome:REACT_31346 "Elongation by Pol eta, Drosophila melanogaster"
Reactome:REACT_31460 "Misinsertion of bases opposite to the lesion by HREV1, Oryza sativa"
Reactome:REACT_31614 "POL Beta mediated incorporation of the first replacement nucleotide, Danio rerio"
Reactome:REACT_31809 "POL Beta mediated incorporation of the first replacement nucleotide, Mus musculus"
Reactome:REACT_32473 "Elongation by Pol eta, Gallus gallus"
Reactome:REACT_32478 "Formation of Okazaki fragments, Xenopus tropicalis"
Reactome:REACT_32689 "Misinsertion of bases opposite to the lesion by HREV1, Gallus gallus"
Reactome:REACT_32853 "The polymerase component of DNA polymerase alpha
Reactome:REACT_33072 "Insertion of correct bases opposite to the lesion by Pol eta, Taeniopygia guttata"
Reactome:REACT_33294 "Insertion of correct bases opposite to the lesion by Pol eta, Sus scrofa"
Reactome:REACT_33524 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Canis familiaris"
Reactome:REACT_34369 "Elongation by Pol eta, Caenorhabditis elegans"
Reactome:REACT_34392 "Misinsertion of bases opposite to the lesion by HREV1, Sus scrofa"
Reactome:REACT_34531 "DNA strand displacement synthesis, Danio rerio"
Reactome:REACT_353 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Homo sapiens"
Reactome:REACT_36881 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Canis familiaris"
Reactome:REACT_41 "DNA strand displacement synthesis, Homo sapiens"
Reactome:REACT_465 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Homo sapiens"
Reactome:REACT_54850 "POL Beta mediated incorporation of the first replacement nucleotide, Canis familiaris"
Reactome:REACT_677 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Homo sapiens"
Reactome:REACT_68438 "Formation of Okazaki fragments, Schizosaccharomyces pombe"
Reactome:REACT_77128 "Formation of C-strand Okazaki fragments, Oryza sativa"
Reactome:REACT_77463 "Misinsertion of bases opposite to the lesion by HREV1, Caenorhabditis elegans"
Reactome:REACT_77925 "The polymerase component of DNA polymerase alpha
Reactome:REACT_78145 "Resynthesis of excised residue, Canis familiaris"
Reactome:REACT_78146 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Taeniopygia guttata"
Reactome:REACT_78405 "Formation of Okazaki fragments, Danio rerio"
Reactome:REACT_78413 "Misinsertion of bases opposite to the lesion by HREV1, Schizosaccharomyces pombe"
Reactome:REACT_78425 "DNA strand displacement synthesis, Xenopus tropicalis"
Reactome:REACT_78678 "The polymerase component of DNA polymerase alpha
Reactome:REACT_78735 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Gallus gallus"
Reactome:REACT_78796 "The polymerase component of DNA polymerase alpha
Reactome:REACT_79308 "Elongation by Pol eta, Taeniopygia guttata"
Reactome:REACT_79568 "Elongation by HREV1 protein, Mycobacterium tuberculosis"
Reactome:REACT_79756 "Resynthesis of excised residue, Bos taurus"
Reactome:REACT_79977 "The polymerase component of DNA polymerase alpha
Reactome:REACT_80037 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Danio rerio"
Reactome:REACT_8004 "The polymerase component of DNA polymerase alpha
Reactome:REACT_80054 "Elongation by Pol eta, Bos taurus"
Reactome:REACT_80171 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Taeniopygia guttata"
Reactome:REACT_8029 "Formation of C-strand Okazaki fragments, Homo sapiens"
Reactome:REACT_80471 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Mus musculus"
Reactome:REACT_80487 "Elongation by Pol eta, Schizosaccharomyces pombe"
Reactome:REACT_80495 "Insertion of correct bases opposite to the lesion by Pol eta, Mus musculus"
Reactome:REACT_80499 "Elongation by Pol eta, Mycobacterium tuberculosis"
Reactome:REACT_80513 "The polymerase component of DNA polymerase alpha
Reactome:REACT_80712 "Misinsertion of bases opposite to the lesion by HREV1, Mus musculus"
Reactome:REACT_80802 "Resynthesis of excised residue, Dictyostelium discoideum"
Reactome:REACT_81020 "Insertion of correct bases opposite to the lesion by Pol eta, Caenorhabditis elegans"
Reactome:REACT_81188 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Gallus gallus"
Reactome:REACT_81625 "DNA strand displacement synthesis, Oryza sativa"
Reactome:REACT_81807 "Insertion of correct bases opposite to the lesion by Pol eta, Mycobacterium tuberculosis"
Reactome:REACT_81927 "Resynthesis of excised residue, Danio rerio"
Reactome:REACT_81968 "The polymerase component of DNA polymerase alpha
Reactome:REACT_82001 "Misinsertion of bases opposite to the lesion by HREV1, Arabidopsis thaliana"
Reactome:REACT_82035 "Misinsertion of bases opposite to the lesion by HREV1, Canis familiaris"
Reactome:REACT_82077 "Insertion of correct bases opposite to the lesion by Pol eta, Danio rerio"
Reactome:REACT_82208 "Elongation by HREV1 protein, Sus scrofa"
Reactome:REACT_82246 "The polymerase component of DNA polymerase alpha
Reactome:REACT_82557 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Mus musculus"
Reactome:REACT_82934 "Elongation by Pol zeta complex, Rattus norvegicus"
Reactome:REACT_83390 "Elongation by HREV1 protein, Gallus gallus"
Reactome:REACT_83447 "Elongation by Pol zeta complex, Canis familiaris"
Reactome:REACT_83674 "Elongation by Pol eta, Saccharomyces cerevisiae"
Reactome:REACT_83763 "Elongation by Pol eta, Mus musculus"
Reactome:REACT_83918 "The polymerase component of DNA polymerase alpha
Reactome:REACT_84028 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Rattus norvegicus"
Reactome:REACT_84123 "DNA strand displacement synthesis, Mus musculus"
Reactome:REACT_84407 "Elongation by HREV1 protein, Saccharomyces cerevisiae"
Reactome:REACT_84633 "Formation of Okazaki fragments, Canis familiaris"
Reactome:REACT_84853 "Misinsertion of bases opposite to the lesion by HREV1, Danio rerio"
Reactome:REACT_84864 "The polymerase component of DNA polymerase alpha
Reactome:REACT_85325 "Formation of Okazaki fragments, Bos taurus"
Reactome:REACT_85611 "The polymerase component of DNA polymerase alpha
Reactome:REACT_86134 "Insertion of correct bases opposite to the lesion by Pol eta, Schizosaccharomyces pombe"
Reactome:REACT_86652 "Elongation by HREV1 protein, Mus musculus"
Reactome:REACT_867 "Elongation by HREV1 protein, Homo sapiens"
Reactome:REACT_86753 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Xenopus tropicalis"
Reactome:REACT_87271 "The polymerase component of DNA polymerase alpha
Reactome:REACT_87439 "DNA strand displacement synthesis, Bos taurus"
Reactome:REACT_87801 "Misinsertion of bases opposite to the lesion by HREV1, Mycobacterium tuberculosis"
Reactome:REACT_88067 "Elongation by Pol zeta complex, Bos taurus"
Reactome:REACT_88473 "The polymerase component of DNA polymerase alpha
Reactome:REACT_88663 "Insertion of correct bases opposite to the lesion by Pol eta, Oryza sativa"
Reactome:REACT_88811 "The polymerase component of DNA polymerase alpha
Reactome:REACT_88997 "The polymerase component of DNA polymerase alpha
Reactome:REACT_89118 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Mus musculus"
Reactome:REACT_89129 "DNA strand displacement synthesis, Canis familiaris"
Reactome:REACT_89399 "Formation of Okazaki fragments, Rattus norvegicus"
Reactome:REACT_89782 "POL Beta mediated incorporation of the first replacement nucleotide, Rattus norvegicus"
Reactome:REACT_89896 "Formation of C-strand Okazaki fragments, Bos taurus"
Reactome:REACT_8992 "Synthesis of full-length duplex viral DNA with a discontinuous plus strand, Homo sapiens"
Reactome:REACT_90310 "The polymerase component of DNA polymerase alpha
Reactome:REACT_90511 "Misinsertion of bases opposite to the lesion by HREV1, Saccharomyces cerevisiae"
Reactome:REACT_90564 "DNA strand displacement synthesis, Sus scrofa"
Reactome:REACT_90691 "Insertion of correct bases opposite to the lesion by Pol eta, Canis familiaris"
Reactome:REACT_9075 "3' PPT-primed initiation of plus-strand DNA synthesis, Homo sapiens"
Reactome:REACT_91 "The polymerase component of DNA polymerase alpha
Reactome:REACT_91123 "The polymerase component of DNA polymerase alpha
Reactome:REACT_91124 "The polymerase component of DNA polymerase alpha
Reactome:REACT_91218 "The polymerase component of DNA polymerase alpha
Reactome:REACT_91365 "Formation of C-strand Okazaki fragments, Rattus norvegicus"
Reactome:REACT_91536 "Elongation by Pol eta, Oryza sativa"
Reactome:REACT_91619 "Elongation by Pol eta, Canis familiaris"
Reactome:REACT_91873 "POL Beta mediated incorporation of the first replacement nucleotide, Xenopus tropicalis"
Reactome:REACT_91890 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Rattus norvegicus"
Reactome:REACT_92243 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Rattus norvegicus"
Reactome:REACT_92358 "POL Beta mediated incorporation of the first replacement nucleotide, Sus scrofa"
Reactome:REACT_92410 "POL Beta mediated incorporation of the first replacement nucleotide, Dictyostelium discoideum"
Reactome:REACT_92575 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Bos taurus"
Reactome:REACT_92627 "Elongation by Pol eta, Danio rerio"
Reactome:REACT_92680 "Elongation by Pol zeta complex, Arabidopsis thaliana"
Reactome:REACT_93171 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Mus musculus"
Reactome:REACT_93535 "Formation of C-strand Okazaki fragments, Arabidopsis thaliana"
Reactome:REACT_93828 "The polymerase component of DNA polymerase alpha
Reactome:REACT_94081 "Elongation by Pol zeta complex, Drosophila melanogaster"
Reactome:REACT_94622 "POL Beta mediated incorporation of the first replacement nucleotide, Bos taurus"
Reactome:REACT_95001 "Formation of Okazaki fragments, Sus scrofa"
Reactome:REACT_95443 "DNA strand displacement synthesis, Rattus norvegicus"
Reactome:REACT_95853 "Resynthesis of excised residue, Xenopus tropicalis"
Reactome:REACT_96429 "The polymerase component of DNA polymerase alpha
Reactome:REACT_96549 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Bos taurus"
Reactome:REACT_97064 "The polymerase component of DNA polymerase alpha
Reactome:REACT_97260 "Formation of C-strand Okazaki fragments, Xenopus tropicalis"
Reactome:REACT_97598 "Elongation by Pol zeta complex, Schizosaccharomyces pombe"
Reactome:REACT_97861 "Elongation by HREV1 protein, Taeniopygia guttata"
Reactome:REACT_97874 "Elongation by HREV1 protein, Oryza sativa"
Reactome:REACT_97969 "Insertion of correct bases opposite to the lesion by Pol eta, Rattus norvegicus"
Reactome:REACT_97975 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Danio rerio"
Reactome:REACT_98393 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Bos taurus"
Reactome:REACT_98499 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Xenopus tropicalis"
Reactome:REACT_98529 "Elongation by HREV1 protein, Danio rerio"
Reactome:REACT_99265 "Elongation by Pol zeta complex, Danio rerio"

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